RESEARCH INITIATIVES/PROJECTS

5. Elucidate SF2/ASF1 ubiquitin dependent degradation pathway by inhibiting SF2/ASF1 specific deubiquitinating enzymes.

6. Cancer Proteomics Tumor Analysis Consortium (CPTAC)

7. Prospective analysis of fresh tumor tissue to understand the changes in tumor immune cells on exposure to immunomodulators using CANScriptTM and other immune markers

8. Evaluation of Exosomal Annexin A2 in serum of TNBC patients

9. Molecular profiling of Sporadic Colorectal Cancer for identification of molecular subtypes of clinical importance

10.  Pilot testing of samples (Acute Leukemia and Ca Lung cases)

11.  Establishment of PAPP-A as a Diagnostic Marker for the Screening of Breast Cancer

12.  To study the correlation between the status of p53 and the expression of Toca-1, FBP17, CIP4, Rapostlin and Endophilin in breast cancer

13.  Can Cyclin D a surrogate marker for bladder cancer? A strategy to identify the prognosticator and a predictor 

14.  Diagnostic Usefulness Of Array Based Oncoscan® Analysis In Detecting Copy Number Variations And Differentiating Chromophobe Renal Carcinoma From Oncocytoma

15.  Validation of Canassist

16. Develop non-coding RNAs based non-invasive diagnostic method for the early detection of the oral squamous cell carcinoma

17.  Study to develop a test to predict resistance to platinum therapy in Ovarian cancer patients’, useful for optimum therapy planning

18.  Evaluation of drugs with known clinical response on cryopreserved tumor tissues in Mitra using CANscriptTM platform”

19.  Study on the role of cadmium toxicity and transcription factor Nkx2.2 in brain tumor development

20.  Study on Expression profile of MicroRNA in Prostate Cancer

21. Study on single Nucleotide Polymorphisms in MicroRNA and Their Correlation with Susceptibility to Colorectal Cancer in Indian Population

22.  Therapeutic Potential of Micro RNAs targeting RNA Polymerase I transcription machinery: A Validation study in Non-Small Cell Lung Cancer

23.  Genomics for Public Health In India. Whole Genome Sequencing for TNBC

24.  Breast Cancer Margin Detection using multispectral Terahertz and Infrared imaging and Spectroscopy

25.  HNSCC proteomics and Transcriptomics

26.  TNBC validation studies

27.  Cancer specific antigen/antibody detection in the plasma and tumor tissue of Breast cancer patients: Development of diagnostic/prognostic tools

28.  Cancer specific antigen detection in the Saliva of cancer patients: Development of diagnostic/prognostic tools

29.  A profiling of differential expression pattern of metastatic suppressor genes in breast cancer –as identification markers for early malignancy. Standardization of the patient derived cell based model system (21HT cell series)

30.  A profiling of differential expression pattern of metastatic suppressor genes in breast cancer – as identification markers for early malignancy

31. Molecular Mechanisms of how telomeres impact global gene expression: potential Role of TRF2 in telomere -chromatin interactions

32.  Therapeutic potential of microRNAs targeting RNA Polymerase I transcription machinery: A validation study in Non-small cell lung cancer

33.  Development of a rapid assay for ctDNA detection in blood for early cancer diagnosis.

34.  Metabolomics-based prediction of response to radiation therapy in Head and Neck cancer

35.  Role of HPV in Breast Cancer

36.  Identification of clinically relevant sphingolipid based biomarkers crucial for breast cancer metastasis

37.  To study the Novel role of cullin 3–SPOP E3 ligase mediated immune surveillance in prostate cancer by promoting the degradation of next generation immune checkpoint inhibitor

38.  Analysis of Molecular Alterations Linked to Aggression and Resistance in Prostate Cancer: An Omics Approach

39.  Large-scale validation and characterization of newly-developed platelet-based liquid biopsy assay in multiple cancer-types (TEP scan)

40.  Molecular Atlas of Oral Cavity Cancer

41.  Functional assay based metastatic characterization of patient tumor samples with colorectal cancers

42.  Functional assay based metastatic characterization of patient tumor samples with multiple epithelial cancers

43. To investigate the role of HPV infection and its association with breast cancer in India: A patient-based exploration study. 100 frozen samples of breast tumor tissue and adjacent normal tissue in RNA later

44. Role of Unusual secondary structures in Lnc RNA function

45.  Functional assay based metastatic characterization of patient tumor samples with colorectal cancers

46.  Proteomic and Metabolomics profiling of HeLa cells: A comparative study with clinical samples

47. Training of an  AI module

48.  Understanding genetic and epigenetic signature of breast cancer metastasis

49. Isolation and characterization of alveolar epithelial type II cells from normal human lung tissues

50.  Elucidation of the role of Protein kinase D (PKD) and PI3 kinase Protein kinase C iota (PKCι) signaling axes in refractory ovarian cancer

51.  Large scale clinical validation of TEP Scan: A comprehensive platelet gene panel for blood based cancer detection

52.  Identification of novel tumor associated target antigens for monoclonal antibody therapy in human cancers

53.  Procurement of biospecimens for biomarker analysis, Qualification and validation

54.  Identification of clinical stage specific differential expression of proteins in colorectal cancer

55. Exploring the mechanisms of autophagy inhibition in pancreatic cancer by small molecules

56.  Looking deep beneath the surface of childhood rhabdomyosarcoma: Machine learning for rhabdomyosarcoma

57.  Developing small molecule inhibitors to target non-genomic androgen signaling and elucidating the role of GPR56 in prostate cancer

58. Proposal for Developing the Cancer Artificial Intelligence (AI) Module

59.  Tumour Microbiota in Breast Cancer: Implications on Pharmacogenomics of Anti-cancer drugs

60.  Identification of clinically actionable bio-signature to incorporate in routine clinical practice for prostate cancer management

61.  To Study the Expression of Prostate Cancer-Associated Genes Involved in the Initiation, Progression and Metastasis of Prostate Cancer

62.  Comparison of RNA sequencing profile using NGS in treatment naïve low to intermediate vs high risk prostate cancer groups in Indian population

63.  Elucidating genetic landscape of gallbladder cancer and establishing patient derived cancer cell lines/xenograft

64.  Investigation Aeitology of early age onset colorectal cancers (EOCRC) using multiomics technology: A case control study

65.  Identification of stage specific differential expression of proteins in CRC

66.  Understanding the interplay of KH-Type splicing regulatory protein (KSRP) and EGFR signaling pathway in cancer

67.  Identification of novel tumor-associated target antigens for monoclonal antibody therapy in human cancers

68.  Tumor microbiota in breast cancer: implication on pharma genomics of anticancer drugs

69. Genomics for Public Health in India

70.  Role of NF-KB & steroid hormones in the pathogensis of gallbladder cancer

71. Delineate molecular mechanism in development of chemo-resistance in non-Hodgkin’s lymphoma

72.  Novel Therapy focusing on the development and commercialization of novel cancer immunotherapies based on tumor infiltrating lymphocytes (TIL)

73.  Validation of usage of Buffy coat/ Leucopaks derived NK (Natural Killer) cells for cellular therapies early research

74.  Thousand Breast cancer Genome Atlas