RESEARCH PROJECTS

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Research Projects
  1. Understanding the role of cyclin F in cancer metabolism
  2. Epigenetic Regulation in Breast Cancer
  3. Concordance of qRTPCR for detection of HER2 neu amplification defined status in relation to IHC and FISH in breast cancer patients
  4. Study the role of hnRNPA1 (RNA binding protein) in glioma cell resistance development
  5. Elucidate SF2/ASF1 ubiquitin dependent degradation pathway by inhibiting SF2/ASF1 specific deubiquitinating enzymes
  6. Cancer Proteomics Tumor Analysis Consortium (CPTAC)
  7. Prospective analysis of fresh tumor tissue to understand the changes in tumor immune cells on exposure to immunomodulators using CANScriptTM and other immune markers
  8. Evaluation of Exosomal Annexin A2 in serum of TNBC patients
  9. Molecular profiling of Sporadic Colorectal Cancer for identification of molecular subtypes of clinical importance
  10.  Pilot testing of samples (Acute Leukemia and Ca Lung cases)
  11.  Establishment of PAPP-A as a Diagnostic Marker for the Screening of Breast Cancer
  12.  To study the correlation between the status of p53 and the expression of Toca-1, FBP17, CIP4, Rapostlin and Endophilin in breast cancer
  13.  Can Cyclin D a surrogate marker for bladder cancer? A strategy to identify the prognosticator and a predictor 
  14.  Diagnostic Usefulness Of Array Based Oncoscan® Analysis In Detecting Copy Number Variations And Differentiating Chromophobe Renal Carcinoma From Oncocytoma
  15.  Validation of Canassist
  16.  Develop non-coding RNAs based non-invasive diagnostic method for the early detection of the oral squamous cell carcinoma
  17.  Study to develop a test to predict resistance to platinum therapy in Ovarian cancer patients’, useful for optimum therapy planning
  18.  Evaluation of drugs with known clinical response on cryopreserved tumor tissues in Mitra using CANscriptTM platform”
  19.  Study on the role of cadmium toxicity and transcription factor Nkx2.2 in brain tumor development
  20.  Study on Expression profile of MicroRNA in Prostate Cancer
  21.  Study on single Nucleotide Polymorphisms in MicroRNA and Their Correlation with Susceptibility to Colorectal Cancer in Indian Population
  22.  Therapeutic Potential of Micro RNAs targeting RNA Polymerase I transcription machinery: A Validation study in Non-Small Cell Lung Cancer
  23.  Genomics for Public Health In India. Whole Genome Sequencing for TNBC
  24.  Breast Cancer Margin Detection using multispectral Terahertz and Infrared imaging and Spectroscopy
  25.  HNSCC proteomics and Transcriptomics
  26.  TNBC validation studies
  27.  Cancer specific antigen/antibody detection in the plasma and tumor tissue of Breast cancer patients: Development of diagnostic/prognostic tools
  28.  Cancer specific antigen detection in the Saliva of cancer patients: Development of diagnostic/prognostic tools
  29.  A profiling of differential expression pattern of metastatic suppressor genes in breast cancer –as identification markers for early malignancy. Standardization of the patient derived cell based model system (21HT cell series)
  30.  A profiling of differential expression pattern of metastatic suppressor genes in breast cancer – as identification markers for early malignancy
  31.  Molecular Mechanisms of how telomeres impact global gene expression: potential Role of TRF2 in telomere -chromatin interactions
  32.  Therapeutic potential of microRNAs targeting RNA Polymerase I transcription machinery: A validation study in Non-small cell lung cancer
  33.  Development of a rapid assay for ctDNA detection in blood for early cancer diagnosis.
  34.  Metabolomics-based prediction of response to radiation therapy in Head and Neck cancer
  35.  Role of HPV in Breast Cancer
  36.  Identification of clinically relevant sphingolipid based biomarkers crucial for breast cancer metastasis
  37.  To study the Novel role of cullin 3–SPOP E3 ligase mediated immune surveillance in prostate cancer by promoting the degradation of next generation immune checkpoint inhibitor
  38.  Analysis of Molecular Alterations Linked to Aggression and Resistance in Prostate Cancer: An Omics Approach
  39.  Large-scale validation and characterization of newly-developed platelet-based liquid biopsy assay in multiple cancer-types (TEP scan)
  40.  Molecular Atlas of Oral Cavity Cancer
  41.  Functional assay based metastatic characterization of patient tumor samples with colorectal cancers
  42.  Functional assay based metastatic characterization of patient tumor samples with multiple epithelial cancers
  43.  To investigate the role of HPV infection and its association with breast cancer in India: A patient-based exploration study. 100 frozen samples of breast tumor tissue and adjacent normal tissue in RNA later
  44.  Role of Unusual secondary structures in Lnc RNA function
  45.  Functional assay based metastatic characterization of patient tumor samples with colorectal cancers
  46.  Proteomic and Metabolomics profiling of HeLa cells: A comparative study with clinical samples
  47.  Training of an  AI module
  48.  Understanding genetic and epigenetic signature of breast cancer metastasis
  49.  Isolation and characterization of alveolar epithelial type II cells from normal human lung tissues
  50.  Elucidation of the role of Protein kinase D (PKD) and PI3 kinase Protein kinase C iota (PKCι) signaling axes in refractory ovarian cancer
  51.  Large scale clinical validation of TEP Scan: A comprehensive platelet gene panel for blood based cancer detection
  52.  Identification of novel tumor associated target antigens for monoclonal antibody therapy in human cancers
  53.  Procurement of biospecimens for biomarker analysis, Qualification and validation
  54.  Identification of clinical stage specific differential expression of proteins in colorectal cancer
  55.  Exploring the mechanisms of autophagy inhibition in pancreatic cancer by small molecules
  56.  Looking deep beneath the surface of childhood rhabdomyosarcoma: Machine learning for rhabdomyosarcoma
  57.  Developing small molecule inhibitors to target non-genomic androgen signaling and elucidating the role of GPR56 in prostate cancer
  58.  Proposal for Developing the Cancer Artificial Intelligence (AI) Module
  59.  Tumour Microbiota in Breast Cancer: Implications on Pharmacogenomics of Anti-cancer drugs
  60.  Identification of clinically actionable bio-signature to incorporate in routine clinical practice for prostate cancer management
  61.  To Study the Expression of Prostate Cancer-Associated Genes Involved in the Initiation, Progression and Metastasis of Prostate Cancer
  62.  Comparison of RNA sequencing profile using NGS in treatment naïve low to intermediate vs high risk prostate cancer groups in Indian population
  63.  Elucidating genetic landscape of gallbladder cancer and establishing patient derived cancer cell lines/xenograft
  64.  Investigation Aeitology of early age onset colorectal cancers (EOCRC) using multiomics technology: A case control study
  65.  Identification of stage specific differential expression of proteins in CRC
  66.  Understanding the interplay of KH-Type splicing regulatory protein (KSRP) and EGFR signaling pathway in cancer
  67.  Identification of novel tumor-associated target antigens for monoclonal antibody therapy in human cancers
  68.  Tumor microbiota in breast cancer: implication on pharma genomics of anticancer drugs
  69.  Genomics for Public Health in India
  70.  Role of NF-KB & steroid hormones in the pathogensis of gallbladder cancer
  71.  Delineate molecular mechanism in development of chemo-resistance in non-Hodgkin’s lymphoma
  72.  Novel Therapy focusing on the development and commercialization of novel cancer immunotherapies based on tumor infiltrating lymphocytes (TIL)
  73.  Validation of usage of Buffy coat/ Leucopaks derived NK (Natural Killer) cells for cellular therapies early research
  74.  Thousand Breast cancer Genome Atlas

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